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Dig Dis Sci. 2009 Jan;54(1):75-9. doi: 10.1007/s10620-008-0498-1. Epub 2008 Oct 30.

The effect of iNOS inhibitors and hyperbaric oxygen treatment in a rat model of experimental colitis.

Author information

1
Division of Internal Medicine, Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey. cnercin@hotmail.com

Abstract

AIM:

Our aim was to investigate the effectiveness of aminoguanidine (AMG), an inducible nitric oxide synthase inhibitor, and hyperbaric oxygen (HBO) treatment in an experimental colitis model.

METHODS:

We induced colitis in rats. In the control group, we applied 2 ml serum physiologic intraperitoneally for 7 days. In the HBO group, 100% oxygen at 2.4 atm pressure was applied for 7 days. In the AMG group, 100 mg/kg AMG was applied intraperitoneally for 7 days. In the HBO + AMG group, HBO and AMG were applied, respectively. At the end of 7 days, rats were sacrificed and the distal 10 cm part of colon was examined macro- and microscopically.

RESULTS:

Severity of colitis and NO activities were reduced by AMG, HBO, and HBO + AMG application. There was histologically significant improvement, especially in the HBO + AMG group.

CONCLUSIONS:

Both HBO and AMG were significantly effective in preventing weight loss, reducing NO activities, and severity of colitis, when comparing HBO and AMG separately.

PMID:
18972208
DOI:
10.1007/s10620-008-0498-1
[Indexed for MEDLINE]

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