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Nat Rev Mol Cell Biol. 2008 Dec;9(12):1004-10. doi: 10.1038/nrm2529. Epub 2008 Oct 30.

Autophagic cell death: the story of a misnomer.

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  • 1Institut Gustave Roussy, F-94805 Villejuif, France. kroemer@igr.fr

Abstract

Dying cells often display a large-scale accumulation of autophagosomes and hence adopt a morphology called autophagic cell death. In many cases, it is agreed that this autophagic cell death is cell death with autophagy rather than cell death by autophagy. Here, we evaluate the accumulating body of literature that argues that cell death occurs by autophagy. We also list the caveats that must be considered when deciding whether or not autophagy is an important effector mechanism of cell death.

PMID:
18971948
PMCID:
PMC2727358
DOI:
10.1038/nrm2529
[PubMed - indexed for MEDLINE]
Free PMC Article
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