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Minerva Med. 2008 Oct;99(5):519-32.

[Molecular aspects of obesity and related-pathologies].

[Article in Italian]

Author information

1
Laboratorio di Analisi Cliniche del dott. A. Montemurro & C. S.a.s., Matera, Italia. giovanni.buonsanti@gmail.com

Abstract

The structure of human genetic machinery aimed at energy homeostasis has been set-up to face food deficiency rather than availability of a larger amount of calories compared with those needed for activities and works characterized by a little expenditure of energy. A epidemiologic-like, global-extended trend of obesity growth is observable, a condition associated with other pathologies that increase mobility and mortality in all ranges of ages. A correct management of obesity is a global challenge that involves both health improvement and socioeconomic aspects (i.e. costs sustained for management of obesity-linked pathologies, such the cardiovascular diseases, the type 2 diabetes as well as some type of tumors or neurologic diseases). This article analyzes recent scientific advancements on the mechanisms linking obesity to type 2 diabetes as well as the adipose tissue and intestinal apparatus' molecular mechanisms that control the energy balance.

PMID:
18971916
[Indexed for MEDLINE]

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