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Cell Cycle. 2008 Nov 1;7(21):3344-54. Epub 2008 Nov 11.

Aging: ROS or TOR.

Author information

1
Ordway Research Institute, and Oncotarget, Albany, New York 12208, USA. Blagosklonny@oncotarget.com

Abstract

It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.

PMID:
18971624
DOI:
10.4161/cc.7.21.6965
[Indexed for MEDLINE]

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