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Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1906-8.

[Genetic polymorphism analysis of 3 short tandem repeat loci on chromosome 21 in Chinese Han population in Shaanxi Province].

[Article in Chinese]

Author information

1
Center for Laboratory Medicine, First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. wx6212@yahoo.cn

Abstract

OBJECTIVE:

To investigate the polymorphism of 3 short tandem repeat (STR) loci D21S1442, D21S1413 and D21S1809 on human chromosome 21 in Shaanxi Han nationality in China.

METHODS:

Blood samples anti-coagulated with EDTA were collected from 160 unrelated Chinese Han individuals in Shaanxi Province. The genomic DNA was extracted with Chelex-100, amplified by PCR and analyzed using PAGE with silver staining.

RESULTS:

Nine, eight and seven alleles were detected at the loci of D21S1442, D21S1413 and D21S1809, respectively. The genotype distributions of all the 3 loci were in accordance with Hardy-Weinberg equilibrium. The heterozygosities of the 3 loci were 0.750, 0.742 and 0.694, respectively. No linkage disequilibrium was found between the loci.

CONCLUSION:

The 3 loci on chromosome 21 have high heterozygosity and polymorphic information content in Shaanxi Han population, suggesting their value as potentially useful genetic markers.

PMID:
18971198
[Indexed for MEDLINE]
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