Detection of homocysteine at carbon nanotube paste electrodes

Nathan S Lawrence; Randhir P Deo; Joseph Wang

doi:10.1016/j.talanta.2003.11.024

Detection of homocysteine at carbon nanotube paste electrodes

Talanta. 2004 May 28;63(2):443-9. doi: 10.1016/j.talanta.2003.11.024.

Authors

Nathan S Lawrence¹, Randhir P Deo, Joseph Wang

Affiliation

¹ Department of Chemistry, New Mexico State University, Las Cruces, NM 88003, USA.

PMID: 18969452
DOI: 10.1016/j.talanta.2003.11.024

Abstract

The use of a carbon-nanotube paste (CNTP) electrode provides an effective means for the determination of homocysteine. A decrease of ca. 120mV in the overpotential for the oxidation of homocysteine compared to a traditional carbon paste electrode, is reported along with greatly enhanced signal-to-noise characteristics. The analytical parameters have been assessed with a linear range from 5 to 200muM and a detection limit of 4.6muM. Furthermore, the generic nature of this increased reactivity of the CNTP surface towards thiol moieties has been demonstrated with cysteine, glutathione and n-acetylcysteine, providing a greatly enhanced electrochemical response compared to the carbon paste electrode.