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Physiol Behav. 1991 Jun;49(6):1283-7.

Lesions of the suprachiasmatic nucleus disrupt circadian locomotor rhythms in the mouse.

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1
Department of Neurology, University of Massachusetts Medical School, Worcester 01655.

Abstract

Entrained and free-running rhythms of wheel-running activity were recorded in male BALB/cByJ mice with electrolytic lesions of the suprachiasmatic nucleus (SCN), site of a circadian pacemaker in mammals. Complete ablation of the nucleus abolished the circadian locomotor rhythm; in some cases, wheel-running was synchronized by a light-dark cycle, but the phase relationship of this activity to the cycle was often aberrant. Unilateral lesions or those missing the SCN did not eliminate rhythmicity.

PMID:
1896511
[Indexed for MEDLINE]
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