Format

Send to

Choose Destination
Curr Opin Struct Biol. 2008 Dec;18(6):734-40. doi: 10.1016/j.sbi.2008.09.010. Epub 2008 Nov 17.

Structural insights into G-protein-coupled receptor activation.

Author information

1
Department of Molecular & Cellular Physiology, Stanford University School of Medicine, USA. bill.weis@stanford.edu

Abstract

G-protein-coupled receptors (GPCRs) are the largest family of eukaryotic plasma membrane receptors, and are responsible for the majority of cellular responses to external signals. GPCRs share a common architecture comprising seven transmembrane (TM) helices. Binding of an activating ligand enables the receptor to catalyze the exchange of GTP for GDP in a heterotrimeric G protein. GPCRs are in a conformational equilibrium between inactive and activating states. Crystallographic and spectroscopic studies of the visual pigment rhodopsin and two beta-adrenergic receptors have defined some of the conformational changes associated with activation.

PMID:
18957321
PMCID:
PMC4019673
DOI:
10.1016/j.sbi.2008.09.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center