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Z Rheumatol. 2008 Nov;67(7):593-5. doi: 10.1007/s00393-008-0381-7.

[Relevance of the gene variant PTPN22 620W for rheumatology].

[Article in German]

Author information

1
Klinische Forschergruppe für Rheumatologie, Abteilung für Rheumatologie und Klinische Immunologie, Universitätsklinikum Freiburg, Breisacher Str. 66 (ZKF), 79106, Freiburg. inga.melchers@uniklinik-freiburg.de

Abstract

PTPN22 620W is regarded as the second most important risk factor for type 1 diabetes and rheumatoid arthritis. Here we describe aspects of the molecular biology of the enzyme and its function, the geographical distribution of the 620W variant, as well as its importance in less frequent rheumatic diseases.

PMID:
18956205
DOI:
10.1007/s00393-008-0381-7
[Indexed for MEDLINE]
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