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Oncogene. 2008 Oct 27;27(50):6452-61. doi: 10.1038/onc.2008.311.

Caspase-independent cell death: leaving the set without the final cut.

Author information

1
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

Abstract

Apoptosis is dependent upon caspase activation leading to substrate cleavage and, ultimately, cell death. Although required for the apoptotic phenotype, it has become apparent that cells frequently die even when caspase function is blocked. This process, termed caspase-independent cell death (CICD), occurs in response to most intrinsic apoptotic cues, provided that mitochondrial outer membrane permeabilization has occurred. Death receptor ligation can also trigger a form of CICD termed necroptosis. In this review, we will examine the molecular mechanisms governing CICD, highlight recent findings demonstrating recovery from conditions of CICD and discuss potential pathophysiological functions of these processes.

PMID:
18955972
PMCID:
PMC2635930
DOI:
10.1038/onc.2008.311
[Indexed for MEDLINE]
Free PMC Article

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