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Am J Alzheimers Dis Other Demen. 2008 Oct-Nov;23(5):439-46. doi: 10.1177/1533317508320084.

The usefulness of cube copying for evaluating treatment of Alzheimer's disease.

Author information

1
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, University Hospital MAS, Malmö, Sweden. sebastian.palmqvist@skane.se

Abstract

AIMS:

Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD.

METHODS:

Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined.

RESULTS:

The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was unchanged.

CONCLUSIONS:

The results indicate that cube copying can be used to evaluate ChEI treatment. It might also show a more long-lasting response to treatment than MMSE. Cube copying only measures a narrow cognitive function and can preferably be used with MMSE, which evaluates visuospatial ability poorly.

PMID:
18955723
DOI:
10.1177/1533317508320084
[Indexed for MEDLINE]

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