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Biochim Biophys Acta. 2009 Apr;1788(4):864-71. doi: 10.1016/j.bbamem.2008.08.027. Epub 2008 Oct 8.

Cytokine regulation of tight junctions.

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1
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.

Abstract

Epithelial and endothelial tight junctions act as a rate-limiting barrier between an organism and its environment. Continuing studies have highlighted the regulation of the tight junction barrier by cytokines. Elucidation of this interplay is vital for both the understanding of physiological tight junction regulation and the etiology of pathological conditions. This review will focus on recent advances in our understanding of the molecular mechanisms of tight junctions modulation by cytokines.

PMID:
18952050
PMCID:
PMC2699410
DOI:
10.1016/j.bbamem.2008.08.027
[Indexed for MEDLINE]
Free PMC Article
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