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Biochim Biophys Acta. 2009 Aug;1788(8):1687-92. doi: 10.1016/j.bbamem.2008.09.013. Epub 2008 Oct 8.

Control of cell selectivity of antimicrobial peptides.

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1
Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. katsumim@pharm.kyoto-u.ac.jp

Abstract

Antimicrobial peptides (AMPs) are promising novel antibiotics, because they exhibit broad antimicrobial spectra and do not easily induce resistance. For clinical applications, it is important to develop potent AMPs with less toxicity against host cells. This review article summarizes the molecular basis for the cell selectivity (bacteria versus host cells) of AMPs and various attempts to control it, including the optimization of physicochemical parameters of peptides, the introduction of D-, fluorinated, and unusual amino acids into peptides, the constraining of peptide conformations, and the modification of peptides by polymers. Pros and cons of these approaches are discussed.

PMID:
18952049
DOI:
10.1016/j.bbamem.2008.09.013
[Indexed for MEDLINE]
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