Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2008 Nov-Dec;1781(11-12):665-84. doi: 10.1016/j.bbalip.2008.09.002. Epub 2008 Oct 7.

Phase diagrams of lipid mixtures relevant to the study of membrane rafts.

Author information

  • 1Unidad de Biofísica (Centro Mixto CSIC-UPV/EHU), and Departamento de Bioquímica, Universidad del País Vasco, P.O. Box 644, 48080 Bilbao, Spain. felix.goni@ehu.es

Abstract

The present paper reviews the phase properties of phosphatidylcholine-sphingomyelin-cholesterol mixtures, that are often used as models for membrane "raft" microdomains. The available data based on X-ray, microscopic and spectroscopic observations, surface pressure and calorimetric measurements, and detergent solubilization assays, are critically evaluated and rationalized in terms of triangular phase diagrams. The remaining uncertainties are discussed specifically and separately from the data on which a consensus appears to exist.

PMID:
18952002
PMCID:
PMC2600854
DOI:
10.1016/j.bbalip.2008.09.002
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center