Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6179-83. doi: 10.1016/j.bmcl.2008.10.014. Epub 2008 Oct 7.

Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics.

Author information

1
Department of Medicinal Chemistry, Rib-X Pharmaceuticals Inc., 300 George Street, Suite 301, New Haven, CT 06511, USA.

Abstract

From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. From this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. The synthesis of these compounds is outlined.

PMID:
18951792
DOI:
10.1016/j.bmcl.2008.10.014
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center