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Am J Hematol. 2008 Dec;83(12):928-31. doi: 10.1002/ajh.21293.

Laboratory testing for fibrinogen abnormalities.

Author information

1
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Abstract

Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered function of fibrinogen, often leading to an increased risk of bleeding. Routine coagulation testing and specialized laboratory investigations can guide diagnosis in patients suspected of having a fibrinogen abnormality. This article summarizes the types of laboratory assays that are used to assess fibrinogen disorders, and key abnormalities found in different types of fibrinogen disorders.

PMID:
18951466
DOI:
10.1002/ajh.21293
[Indexed for MEDLINE]
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