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Fish Shellfish Immunol. 2008 Dec;25(6):782-90. doi: 10.1016/j.fsi.2008.03.020. Epub 2008 Apr 7.

Molecular modelling of co-receptor CD8 alpha alpha and its complex with MHC class I and T-cell receptor in sea bream (Sparus aurata).

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Laboratorio di Bioinformatica e Biologia Computazionale, Istituto di Scienze dell'Alimentazione - CNR, via Roma 52 A/C, 83100 Avellino, Italy.


T-cells are the main actors of cell-mediated immune defence; they recognize and respond to peptide antigens associated with MHC class I and class II molecules. In this paper, we investigated by molecular modelling methods in the teleost sea bream (Sparus aurata) the interaction among the molecules of the tertiary complex CD8/MHC-I/TCR, which determines the T-cell-mediated immunological response to foreign molecules. First, we predicted the three-dimensional structure of CD8 alpha alpha dimer and MHC-I, and, successively, we simulated the CD8 alpha alpha/MHC-I complex. Finally, the 3D structure of the CD8/MHC-I/TCR complex was simulated in order to investigate the possible changes that can influence TCR signalling events.

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