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Med Sci (Paris). 2008 Oct;24(10):828-32. doi: 10.1051/medsci/20082410828.

[Survivin, the starlet of the passenger-protein complex : check-up for its tenth anniversary].

[Article in French]

Author information

1
Inserm U823, Institut Albert Bonniot, Université Joseph Fourier, Domaine de la Merci, 38706 La Tronche Cedex, France. marlene.delacour@ujf-grenoble.fr

Abstract

Ten year after its discovery Survivin has gained a strategic place within the chromosomal passenger complex. Whereas INCENP, Borealin and Aurora B are fully immobile in the complex, Survivin is mobile on centromere. Its mobility is regulated both by phosphorylation and ubiquitination. Survivin is a dynamic messenger that senses the central spindle tension and participates to the control of the mitotic chekpoint. In this review, we have detailed the multiple mitotic activities of Survivin and discussed them in light of the recent reported crystallographic data.

PMID:
18950578
DOI:
10.1051/medsci/20082410828
[Indexed for MEDLINE]
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