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Semin Immunopathol. 2008 Dec;30(4):425-37. doi: 10.1007/s00281-008-0132-5. Epub 2008 Oct 24.

Reconstitution of the immune system after hematopoietic stem cell transplantation in humans.

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Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada.


Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.

[Indexed for MEDLINE]

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