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Nat Rev Cancer. 2008 Nov;8(11):875-9. doi: 10.1038/nrc2522.

Ageing, oxidative stress and cancer: paradigms in parallax.

Author information

1
Christopher C. Benz and Christina Yau are at the Buck Institute for Age Research, Novato, California 94945, USA.

Abstract

Two paradigms central to geroscience research are that aging is associated with increased oxidative stress and increased cancer risk. Therefore, it could be deduced that cancers arising with ageing will show evidence of increased oxidative stress. Recent studies of gene expression in age-controlled breast cancer cases indicate that this deduction is false, posing parallax views of these two paradigms, and highlighting the unanswered question: does ageing cause or simply permit cancer development?

PMID:
18948997
PMCID:
PMC2603471
DOI:
10.1038/nrc2522
[Indexed for MEDLINE]
Free PMC Article

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