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Acta Haematol. 2008;120(2):91-9. doi: 10.1159/000165510. Epub 2008 Oct 24.

Plasmacytoid dendritic cell leukemia with potent antigen-presenting ability.

Author information

1
Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, Japan. naritami@clg.niigata-u.ac.jp

Abstract

We report 2 patients with plasmacytoid dendritic cell leukemia (pDCL) expressing CD4, CD56, CD33, CD36, HLA-DR, CD123, CD86 and CD83 in the absence of lineage markers (myeloid, B, T or natural killer cells) except for CD33. Culturing leukemic blasts of both cases with IL-3 for 4 days increased the expression of surface molecules associated with antigen presentation, e.g. CD1a and CD40. Leukemic blasts of both cases possessed a considerable level of antigen-presenting ability to allogeneic lymphocytes in mixed leukocyte cultures. Culturing the blasts with IL-3 for 4 days markedly increased allogeneic antigen presenting ability. Combined with data showing evident graft-versus-leukemia effects without graft-versus-host disease in a cord blood stem cell transplanted pDCL case, leukemic cells in pDCL may act as potent antigen presenting cells in vivo, too.

PMID:
18948686
DOI:
10.1159/000165510
[Indexed for MEDLINE]

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