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J Int Assoc Physicians AIDS Care (Chic). 2008 Nov-Dec;7(6):283-5. doi: 10.1177/1545109708326090. Epub 2008 Oct 23.

Immune reconstitution inflammatory syndrome presenting as superior vena cava syndrome secondary to Coccidioides lymphadenopathy in an HIV-infected patient.

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Department of Family Medicine, University of California, San Francisco-Fresno Medical Education Program, Fresno, California 93701-2302, USA.


A 39-year-old man living with AIDS presented with a swollen face. He was found to be HIV infected after presenting with Coccidioides pneumonia 2 years previously and was placed on daily fluconazole and then on highly active antiretroviral therapy. Computed tomography confirmed superior vena cava obstruction secondary to lymphadenopathy. Biopsy confirmed coccidioidomycosis with no evidence of malignancy. To our knowledge, this is the first description of superior vena cave syndrome secondary to coccidioidomycosis and the first description of immune reconstitution inflammatory syndrome involving Coccidioides.

[Indexed for MEDLINE]

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