Format

Send to

Choose Destination
J Endocrinol. 2009 Jan;200(1):23-33. doi: 10.1677/JOE-08-0262. Epub 2008 Oct 23.

Essential role of glucose transporter GLUT3 for post-implantation embryonic development.

Author information

1
Department of Pharmacology Toxicology, German Institute of Human Nutrition, Nuthetal, Germany.

Abstract

Deletion of glucose transporter gene Slc2a3 (GLUT3) has previously been reported to result in embryonic lethality. Here, we define the exact time point of growth arrest and subsequent death of the embryo. Slc2a3(-/-) morulae and blastocysts developed normally, implanted in vivo, and formed egg-cylinder-stage embryos that appeared normal until day 6.0. At day 6.5, apoptosis was detected in the ectodermal cells of Slc2a3(-/-) embryos resulting in severe disorganization and growth retardation at day 7.5 and complete loss of embryos at day 12.5. GLUT3 was detected in placental cone, in the visceral ectoderm and in the mesoderm of 7.5-day-old wild-type embryos. Our data indicate that GLUT3 is essential for the development of early post-implanted embryos.

PMID:
18948350
PMCID:
PMC2632781
DOI:
10.1677/JOE-08-0262
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Sheridan PubFactory Icon for PubMed Central
Loading ...
Support Center