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J Biol Chem. 2009 Mar 6;284(10):6027-31. doi: 10.1074/jbc.R800009200. Epub 2008 Oct 22.

Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.

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  • 1Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA.

Abstract

Despite intense interest, the molecular mechanisms underlying the association of apoE4 with Alzheimer disease are not clear. Because the function (or dysfunction) of a protein is based on its structure, this review focuses on the effects of the structural differences among the isoforms on neurodegeneration. Understanding how apoE4 structure impacts neurodegeneration is likely to provide mechanistic insight as well as potential therapeutic approaches to blunt or reduce its effects.

PMID:
18948255
PMCID:
PMC2649104
DOI:
10.1074/jbc.R800009200
[PubMed - indexed for MEDLINE]
Free PMC Article
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