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J Biol Chem. 2009 Mar 6;284(10):6033-7. doi: 10.1074/jbc.R800030200. Epub 2008 Oct 22.

Relevance of transgenic mouse models to human Alzheimer disease.

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  • 1Department of Neurobiology and Behavior and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697-4545, USA.


During the past 2 decades, the elucidation of susceptibility and causative genes for Alzheimer disease as well as proteins involved in the pathogenic process has greatly facilitated the development of genetically altered mouse models. These models have played a major role in defining critical disease-related mechanisms and in evaluating novel therapeutic approaches, with many treatments currently in clinical trial owing their origins to studies initially performed in mice. This review discusses the utility of transgenic mice as a research tool and their contributions to our understanding of Alzheimer disease.

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