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Curr Opin Struct Biol. 2008 Dec;18(6):714-25. doi: 10.1016/j.sbi.2008.09.008. Epub 2008 Nov 7.

The multienzyme architecture of eukaryotic fatty acid synthases.

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1
Institute of Molecular Biology and Biophysics, ETH Zurich, 8093 Zurich, Switzerland.

Abstract

Eukaryotic fatty acid synthases (FASs) are huge multifunctional enzymes that carry out all enzymatic steps essential for fatty acid biosynthesis. Recent crystallographic studies provide new insights into the architecture of the two distinct eukaryotic FAS systems, the 2.6 MDa heterododecameric fungal and the 540 kDa dimeric animal FAS. In this review, we compare the fundamentally different organization of these two megasynthases and discuss the structural principles of enzyme integration and substrate shuttling in FAS multienzymes.

PMID:
18948193
DOI:
10.1016/j.sbi.2008.09.008
[Indexed for MEDLINE]
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