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Bioorg Med Chem Lett. 2008 Dec 1;18(23):6175-8. doi: 10.1016/j.bmcl.2008.10.011. Epub 2008 Oct 7.

Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.

Author information

1
Department of Medicinal Chemistry, Rib-X Pharmaceuticals Inc., 300 George Street, Suite 301, New Haven, CT 06511, USA.

Abstract

We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.

PMID:
18947996
DOI:
10.1016/j.bmcl.2008.10.011
[Indexed for MEDLINE]

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