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Bioorg Med Chem Lett. 2008 Dec 1;18(23):6251-4. doi: 10.1016/j.bmcl.2008.09.094. Epub 2008 Oct 1.

The discovery of equipotent PPARalpha/gamma dual activators.

Author information

1
Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Qu├ębec, 91951 Les Ulis, France. paul.martres@gsk.com

Abstract

We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

PMID:
18947994
DOI:
10.1016/j.bmcl.2008.09.094
[Indexed for MEDLINE]

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