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Clin Neurol Neurosurg. 2009 Jan;111(1):54-6. doi: 10.1016/j.clineuro.2008.07.007. Epub 2008 Oct 22.

Association of a history of varicella virus infection with multiple sclerosis.

Author information

1
Neurodegenerative Diseases Clinical Research Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.

Abstract

OBJECTIVE:

To analyze the association of a previous history of varicella virus infection with multiple sclerosis (MS) and its subtypes.

MATERIAL AND METHODS:

We performed a case-control study including 126 cases and 157 controls. Subjects were divided into subgroups according to MS subtype and the history of varicella virus infection along with other variables was assessed.

RESULTS:

History of varicella zoster virus (VZV) infection was positive in 42% of controls and 66% of MS cases (p<or=0.001). Patients with a history of VZV infection had a threefold risk increase of having MS. Regarding MS subtypes, relapsing-remitting (RR) MS had four times the risk and secondary progressive had a threefold increase in risk when compared with control patients.

CONCLUSIONS:

An association between varicella infection history and MS was found, particularly in the RR subtype.

PMID:
18947921
DOI:
10.1016/j.clineuro.2008.07.007
[Indexed for MEDLINE]

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