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Neurophysiol Clin. 2008 Oct;38(5):289-95. doi: 10.1016/j.neucli.2008.08.003. Epub 2008 Sep 18.

Modulating cerebello-thalamocortical pathways by neuronavigated cerebellar repetitive transcranial stimulation (rTMS).

Author information

1
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitaetsstrasse, 84, 93053 Regensburg, Germany. Berthold.Langguth@medbo.de

Abstract

OBJECTIVES:

Increasing evidence suggests that dysfunctions of the cortico-cerebello-thalamocortical circuit are involved in the pathophysiology of neuropsychiatric disorders. This study explores the effects of cerebellar repetitive transcranial magnetic stimulation (rTMS) on cerebello-thalamocortical pathways.

METHODS:

Ten healthy volunteers received MRI-guided rTMS in four separate sessions (120% motor threshold, 1000 stimuli) over either the medial or the right lateral cerebellum using frequencies of 1 and 10 Hz. Motor cortex excitability was assessed before and after the intervention by paired-pulse transcranial magnetic stimulation.

RESULTS:

Depending on stimulation frequency, cerebellar rTMS differentially modified intracortical inhibition. Low frequency rTMS increased short intracortical inhibition (SICI), whereas high frequency rTMS had no significant effect on SICI.

CONCLUSIONS:

These results suggest that rTMS over the cerebellum can modulate cerebello-thalamocortical pathways in a frequency-specific manner.

PMID:
18940616
DOI:
10.1016/j.neucli.2008.08.003
[Indexed for MEDLINE]

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