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Hum Immunol. 2008 Dec;69(12):837-9. doi: 10.1016/j.humimm.2008.09.008. Epub 2008 Oct 20.

Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease.

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Institute of Neurology, Department of Neurosciences, Catholic University, Rome, Italy.


Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response.

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