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Genet Test. 2008 Dec;12(4):537-40. doi: 10.1089/gte.2008.0034.

Estrogen receptor 2 polymorphism and carotid intima-media thickness.

Author information

1
Department of Medical Biochemistry, University of Tampere Medical School , Tampere, Finland. seppo.nikkari@uta.fi

Abstract

AIMS:

The present study was designed to investigate the effects of estrogen receptor 2 gene (ESR2) rs1256049 polymorphism to carotid artery intima-media thickness (CIMT), as part of the Cardiovascular Risk in Young Finns Study.

RESULTS:

The frequencies of ESR2 genotypes G/G, G/A, and A/A were 85.1%, 14.3%, and 0.7%, respectively, in the whole study population (n = 2211). Compared with subjects with genotype GG, those with the A allele had higher mean CIMT (p = 0.004) and maximal CIMT (p = 0.005).

CONCLUSIONS:

In a Finnish population, the ESR2 rs1256049 polymorphism A allele is associated with preclinical atherosclerosis in young adulthood. Our results and those of others also suggest that some effects of this genetic variation may be population specific.

PMID:
18939943
DOI:
10.1089/gte.2008.0034
[Indexed for MEDLINE]

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