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J Am Chem Soc. 2008 Nov 19;130(46):15279-81. doi: 10.1021/ja805948u. Epub 2008 Oct 22.

Photoswitchable nanoparticles enable high-resolution cell imaging: PULSAR microscopy.

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1
Pacific Northwest National Laboratory, Richland, Washington 99352, USA.

Abstract

Beyond-diffraction-limit optical imaging of cells will reveal biological mechanisms, cellular structures, and physiological processes in nanometer scale. Harnessing the photoswitching properties of spiropyran fluorophores, we achieved nanoresolution fluorescence imaging using photoactuated unimolecular logical switching attained reconstruction (PULSAR) microscopy. The PULSAR microscope successfully resolved nanostructures and subcellular organelles when the photoswitchable nanoparticles containing spiropyran dyes were used as fluorescent probes.

PMID:
18939833
PMCID:
PMC2651006
DOI:
10.1021/ja805948u
[Indexed for MEDLINE]
Free PMC Article
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