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Therapie. 2008 Jul-Aug;63(4):333-8. doi: 10.2515/therapie:2008048. Epub 2008 Oct 22.

[Analgesic activity of different nonvolatile extracts of Nepeta atlantica Ball and Nepeta Tuberosa L. ssp. reticulata (Desf.) Maire].

[Article in French]

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Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Faculté des Sciences, Rabat, Morocco.


Different extracts of Nepeta atlantica Ball and Nepeta tuberosa L. ssp. reticulata (Desf.) Maire contain mainly secondary metabolites with iridoïd lactonic and glucosidic type, also with triterpine lupan type.The aerial part of each species is crushed, then extracted in methanol by cold maceration, called global extracts. The global extracts will be extracted through various solvents: initially by hexane, then by dichloromethane, after that by ethyl acetate and at the end by buthanol. Each one of the obtained extracts will be used for the following trials: i) Tail flick trial on the rat for central morphine-like analgesic activity; ii) Koster trial on the mouse for peripheral analgesic activity. The evaluation of the central and peripheral analgesic activities for the pre-cited extracts was realized after optimal doses determination of the global extracts activities for both species.The peripheral analgesic activity test on the mouse showed that, for 60 mg/kg intra peritoneum (IP), the hexanic, dichloromethanic, ethyl acetate and butanic extracts have a protection power against abdominal cramp respectively around 89.78%, 81.73%, 70.9% et 69.05% for Nepeta atlantica Ball, and around 89.16%, 82.98%, 71.52% et 70.27% for Nepeta tuberosa L. ssp. reticulata.Central morphine-like analgesic activity on the rat showed that, for both spices under 60 mg/kg IP, the central analgesic activity effect is significantly for two extracts only: dichloromethane and ethyl acetate.

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