Measurement of elastic properties of prostate cancer cells using AFM

Analyst. 2008 Nov;133(11):1498-500. doi: 10.1039/b803355b. Epub 2008 Jul 25.

Abstract

This communication reports that three prostate cancer cells of differing metastatic potential were discriminated based on their Young's moduli (LNCaP - 287 +/- 52 N m(-2), PC-3 - 1401 +/- 162 N m(-2) and BPH - 2797 +/- 491 N m(-2)) which were determined using AFM and the Hertz model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / pathology*
  • Cell Line, Tumor
  • Elasticity
  • Humans
  • Male
  • Microscopy, Atomic Force
  • Neoplasm Staging
  • Prostatic Neoplasms / pathology*