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J Nutr. 2008 Nov;138(11):2284-8. doi: 10.3945/jn.108.096347.

Hepcidin regulation of iron transport.

Author information

1
Department of Exercise and Nutrition Sciences, University at Buffalo, the State University of New York, Buffalo, NY 14214, USA.

Abstract

The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.

PMID:
18936232
PMCID:
PMC2764359
DOI:
10.3945/jn.108.096347
[Indexed for MEDLINE]
Free PMC Article

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