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Antimicrob Agents Chemother. 2009 Feb;53(2):772-5. doi: 10.1128/AAC.01124-08. Epub 2008 Oct 20.

Posaconazole mono- or combination therapy for treatment of murine zygomycosis.

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1
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, 90502, USA. ibrahim@labiomed.org

Abstract

We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.

PMID:
18936190
PMCID:
PMC2630615
DOI:
10.1128/AAC.01124-08
[Indexed for MEDLINE]
Free PMC Article
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