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Bioinformatics. 2008 Dec 15;24(24):2936-7. doi: 10.1093/bioinformatics/btn540. Epub 2008 Oct 20.

REJECTOR: software for population history inference from genetic data via a rejection algorithm.

Author information

1
Department of Anthropology, Stanford University, Stanford, CA 94305, USA. mjobin@stanford.edu

Abstract

We introduce REJECTOR, software for parameter estimation and comparison of alternate models of population history from genetic data via a rejection algorithm. Through coalescent simulation, REJECTOR generates numerous gene genealogies, and hence simulated data, under a model of population history specified by the user. Summary statistics derived from such simulated data are compared with observed statistics, leading to acceptance or rejection of a given set of parameter values. We performed tests of the software using known parameter values in order to assess the inferential power provided by each summary statistic. The tests demonstrate the precision and accuracy of estimation made possible using this approach.

AVAILABILITY:

http://www.rejector.org

PMID:
18936052
PMCID:
PMC2639306
DOI:
10.1093/bioinformatics/btn540
[Indexed for MEDLINE]
Free PMC Article

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