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Fertil Steril. 2009 Sep;92(3):1053-8. doi: 10.1016/j.fertnstert.2008.07.1757. Epub 2008 Oct 18.

Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome.

Author information

1
Division of Endocrinology and Metabolism, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.

Abstract

OBJECTIVE:

To determine the effect of treatment with vitamin D(3) analogue in the parameters of glucose metabolism in obese women with polycystic ovary syndrome (PCOS).

DESIGN:

Observational study.

SETTING:

Obese women with PCOS in an academic research environment.

PATIENT(S):

Fifteen obese women (mean age 28 +/- 1.3 years, mean body mass index 32.55 +/- 0.43) with documented chronic anovulation and hyperandrogenism were recruited into the study.

INTERVENTION(S):

Alphacalcidol (1-alpha-hydroxyvitamin D(3)) was administered orally 1 microg/day for 3 months. All subjects underwent a frequently sampled IV glucose tolerance test after a 10- to 12-hour overnight fast during a spontaneous bleeding episode before and after treatment with alphacalcidol.

MAIN OUTCOME MEASURE(S):

Peripheral insulin resistance and insulin effectiveness were estimated with minimal model.

RESULT(S):

The first phase of insulin secretion was significantly increased after treatment with alphacalcidol. A favorable statistically significant change also was observed in the lipid profile.

CONCLUSION(S):

Treatment with the vitamin D(3) analogue (alphacalcidol) could be of value in the management of PCOS.

[Indexed for MEDLINE]

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