Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2008 Oct;18(5):404-10. doi: 10.1016/j.gde.2008.10.001. Epub 2008 Oct 16.

Eloquent silence: developmental functions of Class I histone deacetylases.

Author information

1
MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom. v.t.cunliffe@sheffield.ac.uk

Abstract

Histone deacetylases (HDACs) are essential catalytic components of the transcription silencing machinery and they play important roles in the programming of multicellular development. HDACs are present within multisubunit protein complexes, other components of which govern HDAC target gene specificity by controlling interactions with sequence-specific DNA-binding proteins. Here, I review the different developmental roles of the Sin3, NuRD, CoREST and NCoR/SMRT Class I HDAC complexes. With their distinct subunit composition, these versatile molecular devices function in many different settings, to promote axis specification and tissue patterning, to maintain stem cell pluripotency, facilitate self-renewal, guide lineage commitment and drive cell differentiation.

PMID:
18929655
PMCID:
PMC2671034
DOI:
10.1016/j.gde.2008.10.001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center