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Trends Mol Med. 2008 Nov;14(11):495-502. doi: 10.1016/j.molmed.2008.09.003. Epub 2008 Oct 15.

The role of oxidative stress and NADPH oxidase in cerebrovascular disease.

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Departments of Internal Medicine and Pharmacology, Division of Cardiovascular Diseases, Cardiovascular Center, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.


The study of reactive oxygen species (ROS) and oxidative stress remains a very active area of biological research, particularly in relation to cellular signaling and the role of ROS in disease. In the cerebral circulation, oxidative stress occurs in diverse forms of disease and with aging. Within the vessel wall, ROS produce complex structural and functional changes that have broad implications for regulation of cerebral perfusion and permeability of the blood-brain barrier. These oxidative-stress-induced changes are thought to contribute to the progression of cerebrovascular disease. Here, we highlight recent findings in relation to oxidative stress in the cerebral vasculature, with an emphasis on the emerging role for NADPH oxidases as a source of ROS and the role of ROS in models of disease.

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