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Trends Biochem Sci. 2008 Dec;33(12):565-8. doi: 10.1016/j.tibs.2008.09.005. Epub 2008 Oct 15.

mTOR signaling: RAG GTPases transmit the amino acid signal.

Author information

1
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. shaw@salk.edu

Abstract

mTOR (mammalian target of rapamycin) is a highly conserved nutrient-responsive regulator of cell growth that is found in all eukaryotes. The mechanism by which amino acids signal to mTOR has remained one of the largest outstanding questions in the field. Two recent complimentary studies provide compelling evidence that the Rag family of small GTPases is both necessary and sufficient to transmit a positive signal from amino acids to mTOR.

PMID:
18929489
PMCID:
PMC2677387
DOI:
10.1016/j.tibs.2008.09.005
[Indexed for MEDLINE]
Free PMC Article

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