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J Clin Anesth. 2008 Sep;20(6):437-41. doi: 10.1016/j.jclinane.2008.04.008.

Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations.

Author information

1
Department of Anaesthesiology and Reanimation, Karaelmas University Faculty of Medicine Zonguldak, Turkey. periayogluzku@yahoo.com

Abstract

STUDY OBJECTIVE:

To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations.

DESIGN:

Randomized, placebo-controlled study.

SETTING:

Univesity medical center.

PATIENTS:

80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations.

INTERVENTIONS:

Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one microg kg(-1), then intraoperative maintenance was supplied with dexmedetomidine 0.7 microg kg(-1) hour(-1). Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one microg kg(-1) was given.

MEASUREMENTS:

Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded.

MAIN RESULTS:

Group SD had less bleeding and lower bleeding scores (P < 0.05). In addition, this group received less intraoperative fentanyl (P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 +/- 58.8 vs 110.0 +/- 81.0 microg) (P < 0.05).

CONCLUSION:

Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations.

PMID:
18929284
DOI:
10.1016/j.jclinane.2008.04.008
[Indexed for MEDLINE]

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