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Prog Brain Res. 2008;173:303-21. doi: 10.1016/S0079-6123(08)01122-9.

Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.

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1
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Abstract

Here we review how mouse studies are contributing to understanding glaucoma. We include discussion of aqueous humor drainage and intraocular pressure elevation, because new treatments to avoid exposure to high pressure will indirectly protect neurons from glaucoma, and complement direct neuroprotective strategies. We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies.

PMID:
18929118
DOI:
10.1016/S0079-6123(08)01122-9
[Indexed for MEDLINE]

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