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Am J Obstet Gynecol. 2008 Oct;199(4):406.e1-4. doi: 10.1016/j.ajog.2008.06.017.

Contemporary outcomes with the latest 1000 cases of multifetal pregnancy reduction (MPR).

Author information

1
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai School of Medicine, New York, NY, USA. joanne.stone@mssm.edu

Abstract

OBJECTIVE:

This study was undertaken to report on the outcome of multifetal pregnancy reduction in the most up-to-date largest single center experience with this procedure, and compare the outcome to the first 1000 cases performed at the same institution.

STUDY DESIGN:

1000 consecutive cases of multifetal pregnancy reduction performed at the Mount Sinai Medical Center between the years 1999-2006 were identified. Pregnancy outcomes were retrieved from a large database as well as chart review. Differences in means and proportions were evaluated by analysis of variance, chi-square, Cochran-Armitage test for trend or 2-tailed Fisher exact test as appropriate.

RESULTS:

Outcomes were available on 841 cases, for a follow-up rate of 84.1%; 95.2% of patients delivered after 24 weeks, for a complete loss rate of 4.7%. There was a significant trend toward decreasing loss rates with decreasing starting numbers. Mean gestational age at delivery was later, and birthweights greater, for reduction to singletons vs twins.

CONCLUSION:

Loss rates after multifetal pregnancy reduction have remained stable at 4.7%. The lowest loss rate occurred in the patients reducing from twins to a singleton (2.1%). Reduction to a singleton was also associated with higher birthweights and lower rates of preterm deliveries.

PMID:
18928991
DOI:
10.1016/j.ajog.2008.06.017
[Indexed for MEDLINE]

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