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Nat Rev Drug Discov. 2008 Nov;7(11):900-7. doi: 10.1038/nrd2684. Epub 2008 Oct 17.

Genomic-scale prioritization of drug targets: the TDR Targets database.

Author information

1
Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, San Martín 1650, Buenos Aires, Argentina. fernan@unsam.edu.ar

Abstract

The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.

PMID:
18927591
PMCID:
PMC3184002
DOI:
10.1038/nrd2684
[Indexed for MEDLINE]
Free PMC Article
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