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Nat Rev Genet. 2008 Nov;9(11):883-90. doi: 10.1038/nrg2467.

Epigenome dynamics: a quantitative genetics perspective.

Author information

1
Frank Johannes and Ritsert C. Jansen are at the Groningen Bioinformatics Centre, University of Groningen, NL-9751 NN, Haren, The Netherlands.

Abstract

Classically, quantitative geneticists have envisioned DNA sequence variants as the only source of heritable phenotypes. This view should be revised in light of accumulating evidence for widespread epigenetic variation in natural and experimental populations. Here we argue that it is timely to consider novel experimental strategies and analysis models to capture the potentially dynamic interplay between chromatin and DNA sequence factors in complex traits.

PMID:
18927581
DOI:
10.1038/nrg2467
[Indexed for MEDLINE]

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