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Bioorg Med Chem Lett. 2008 Dec 1;18(23):6222-6. doi: 10.1016/j.bmcl.2008.09.102. Epub 2008 Oct 2.

Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists.

Author information

1
Department of Chemistry, Metabolic Pathways Centre for Excellence in Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA. joseph.p.marino@gsk.com

Abstract

High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.

PMID:
18926700
DOI:
10.1016/j.bmcl.2008.09.102
[Indexed for MEDLINE]

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