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Immunobiology. 2008;213(9-10):701-13. doi: 10.1016/j.imbio.2008.07.008. Epub 2008 Sep 7.

From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection.

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Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.


Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection.

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