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Cell Mol Life Sci. 2009 Feb;66(3):407-22. doi: 10.1007/s00018-008-8303-z.

Dynamic protein methylation in chromatin biology.

Author information

1
The Structural Genomics Consortium, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.

Abstract

Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals.

PMID:
18923809
PMCID:
PMC2794343
DOI:
10.1007/s00018-008-8303-z
[Indexed for MEDLINE]
Free PMC Article

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